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Insulin resistance can lead to reduction in ammonium production in the renal proximal tubule resulting in lower urine pH 41

In contrast, daily administration of l-carnitine (200 mg/kg/day) for 28 successive days resulted in a significant 84% and 82% increase in AMPK-2 level in serum and cardiac tissues, respectively, as compared to the control group

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Conversely, when the demand for NADPH increasessuch as during fatty acid synthesis, cholesterol synthesis, or detoxification of reactive oxygen species (ROS)the levels of NADP+ rise, relieving the inhibition on G6PD and accelerating the oxidative phase of the PPP

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